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KMID : 0352119960120030368
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Journal of Kyung Hee University
1996 Volume.12 No. 3 p.368 ~ p.378
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The Effects of Dojeok-san on the Hemodynamic Function in the Isolated Perfused Rat Heart
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Abstract
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In order to verify the cardiovascular hemodynamic function of Dojeok-san, the experiment was performed in rats. Fourteen rat hearts were perfused by the Langendorff technique with modified 37℃Krebs-Henseleit's buffer solution at a constant
perfusion
pressure.
They are randomly assigned to one of two groups, supplied with either normal saline or Dojeok-san administration.
Heart rate, left ventricular pressure, +dp/dt maximum, -dp/dt maximum, -dp/dt/+dp/dt ratio, coronary outflow were evaluated at baseline and after the administration of either normal saline or Dojeok-san.
@ES The results are summarized as follows:
@EN 1. No significant effects of Dojeok-san were observed on the heart rate.
2. Dojeok-san remarkably increased left ventricular pressure (P<0.001).
3. Dojeok-san also significantly increased both +dp/dt max and -dp/dt max, and this explains Dojeok-san has probably cardiotonic effects (p<0.001).
4. No significant effects on -dp/dt/+dp/dt ratio were observed.
5. No significant effects of Dojeok-san were observed on the coronary outflow.
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KEYWORD
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